Polysialic acid and activity-dependent synapse remodeling
نویسندگان
چکیده
منابع مشابه
Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation.
Maintaining a proper balance between excitation and inhibition is essential for the functioning of neuronal networks. However, little is known about the mechanisms through which excitatory activity can affect inhibitory synapse plasticity. Here we used tagged gephyrin, one of the main scaffolding proteins of the postsynaptic density at GABAergic synapses, to monitor the activity-dependent adapt...
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The spread of electrical activity in a dendritic tree is shaped, in part, by its morphology. Conversely, experimental evidence is growing that electrical and chemical activity can slowly shape the morphology of the dendrite. In this theoretical study, the dendritic spines are dynamic elements, with biophysical properties that change in response to patterns of electrical activity. Recent experim...
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Synaptic actin has now been shown to change shape in response to stimulation. The cytoskeleton may therefore be pivotal in integrating molecular and morphological changes associated with synaptic plasticity and coordinating such changes across pre- and postsynaptic compartments.
متن کاملRegulation of hippocampal synapse remodeling by epileptiform activity.
We examined the regulation of dendritic spines and synapses by epileptiform activity (EA) in rat hippocampal slice cultures. EA, which was induced by a GABA(A) receptor inhibitor, gabazine, reduced pyramidal neuron spine density by approximately 50% after 48 h and also caused an increase in the average length of remaining spines. To directly determine the effects of EA on synapses, we used fluo...
متن کاملCell surface expression of polysialic acid on NCAM is a prerequisite for activity-dependent morphological neuronal and glial plasticity.
Polysialic acid (PSA) on the extracellular domain of the neural cell adhesion molecule (NCAM) reduces cell adhesion and is considered an important regulator of cell surface interactions. The hypothalamo-neurohypophysial system (HNS), whose glia, neurons, and synapses undergo striking, reversible morphological changes in response to physiological stimulation, expresses high levels of PSA-NCAM th...
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ژورنال
عنوان ژورنال: Cell Adhesion & Migration
سال: 2009
ISSN: 1933-6918,1933-6926
DOI: 10.4161/cam.3.1.7258